Albumin receptor (with specifics: GP60 [albondin], Megalin, Cubilin, and sometimes SPARC or FcRn)

The "albumin receptor-mediated uptake" pathway refers to the cellular internalization of albumin via specific cell surface receptors, most notably GP60 (also known as albondin), Megalin, and Cubilin. These receptors are expressed in endothelial and renal tubular cells, among others, and are essential for maintaining plasma protein homeostasis, nutrient transport, and cellular signaling. In the endothelium, the GP60 receptor mediates caveolae-dependent transcytosis of albumin across the vessel wall, while in the kidney proximal tubule, albumin is reabsorbed from the filtrate primarily by the Megalin/Cubilin receptor complex[1][3][5]. This pathway is exploited for targeted drug delivery in oncology and other fields, with several approved drugs (e.g., Abraxane) utilizing this mechanism. However, the term "Albumin receptor-mediated uptake" is not a canonical protein name, but an umbrella term for these receptor-mediated processes; the specific proteins involved should be individually named for accurate database representation[3][5].

Other names

Albumin-binding receptorGP60 (albondin)MegalinCubilinSecreted protein acidic and rich in cysteine (SPARC)Neonatal Fc receptor (FcRn)

Receptor-mediated endocytosis/transcytosis to deliver cargo across endothelium or into tissues Targeted delivery of drug-albumin conjugates via enhanced receptor expression (e.g., in tumors)